Discovery of a series of (4,5-dihydroimidazol-2-yl)-biphenylamine 5-HT7 agonists

Vinod Parikh; Willard M Welch; Anne W Schmidt

doi:10.1016/s0960-894x(02)00925-3

Discovery of a series of (4,5-dihydroimidazol-2-yl)-biphenylamine 5-HT7 agonists

Bioorg Med Chem Lett. 2003 Jan 20;13(2):269-71. doi: 10.1016/s0960-894x(02)00925-3.

Authors

Vinod Parikh¹, Willard M Welch, Anne W Schmidt

Affiliation

¹ Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA. parikh@groton.pfizer.com

PMID: 12482437
DOI: 10.1016/s0960-894x(02)00925-3

Abstract

A novel (4,5-dihydroimidazol-2-yl)-biphenylamine series of 5-HT(7) agonist compounds was developed from a structurally related lead compound 1. The newly discovered series is exemplified by compound 2 that possesses high affinity for 5-HT(7) receptors and shows intrinsic agonist activity in functional assays. This new series has significant alpha(1) and alpha(2) activities perhaps due to the presence of the 2-aminoimidazoline moiety.

MeSH terms

Aminobiphenyl Compounds / chemical synthesis*
Aminobiphenyl Compounds / pharmacology*
Animals
Blood Pressure / drug effects
Drug Evaluation, Preclinical
Imidazoles / chemical synthesis*
Imidazoles / pharmacology*
In Vitro Techniques
Indicators and Reagents
Magnetic Resonance Spectroscopy
Mass Spectrometry
Rats
Receptors, Serotonin / drug effects*
Serotonin Receptor Agonists / chemical synthesis*
Serotonin Receptor Agonists / pharmacology*
Spectrophotometry, Infrared

Substances

Aminobiphenyl Compounds
Imidazoles
Indicators and Reagents
Receptors, Serotonin
Serotonin Receptor Agonists
serotonin 7 receptor